![]() ![]() The IRB of University of Iowa gave ethical approval of this work. The details of the IRB/oversight body that provided approval or exemption for the research described are given below: ![]() I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained. National Institute of General Medical Sciences (1R01 DC016038, PI: He) Author Declarations National Institute on Deafness and Other Communicative Disorders (P50 DC 000242, PI: Gantz 1R01 DC017846, PI: He R21 DC019458, PI: He) ![]() MRH is co-founder and Chief Medical Officer for iotaMotion, Inc.Īll other authors declare that they have no conflict of interest. These results provide a new application of post-operative ECoG as an objective tool to monitor residual hearing and understand the pathophysiology of delayed hearing loss. ![]() The slope did not distinguish between subjects with stable hearing and subjects with delayed loss of hearing. CM and ANN thresholds increased (worsened) while CM and ANN amplitudes decreased (worsened) for those with delayed hearing loss. Results showed that CM and ANN thresholds and amplitudes were stable in CI users with preserved residual hearing. Longitudinal linear mixed effects models were used study trends in ECoG thresholds, slopes, and amplitudes for these two categories of subjects. Subjects were categorized as having stable hearing or loss of hearing. The threshold, slope, and suprathreshold amplitude at a fixed stimulation level was obtained from each growth function at each time point. At each test session, ECoG amplitude growth functions for several low-frequency stimuli were obtained. These measures were obtained longitudinally over the course of CI use. In the present study, electrocochleography (ECoG) was used to study cochlear microphonic (hair cell response) and auditory nerve neurophonic (neural response) in patients with preserved hearing and patients with loss of hearing. However, 30-40% of EAS CI users experience a partial loss of hearing up to 30 dB after surgery. As a result, these patients benefit from combined electric-acoustic stimulation (EAS) post-operatively. Minimally traumatic surgical techniques and advances in cochlear implant (CI) electrode array designs have allowed acoustic hearing present in a CI candidate prior to surgery to be preserved post-operatively. ![]()
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